The Panacea of Human Aging: Calorie Restriction Versus Exercise
نویسندگان
چکیده
منابع مشابه
Aging, adiposity, and calorie restriction.
CONTEXT Excessive calorie intake and subsequent obesity increases the risk of developing chronic disease and decreases life expectancy. In rodent models, calorie restriction with adequate nutrient intake decreases the risk of developing chronic disease and extends maximum life span. OBJECTIVE To evaluate the physiological and clinical implications of calorie restriction with adequate nutrient...
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In the 75 years since the seminal observation of Clive McCay that restriction of calorie intake extends the lifespan of rats, a great deal has been learned about the effects of calorie restriction (CR; reduced intake of a nutritious diet) on aging in various short-lived animal models. Studies have demonstrated many beneficial effects of CR on health, the rate of aging, and longevity. Two prospe...
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Among diverse environmental factors that modify aging, diet has a profound effect. Calorie restriction (CR), which entails reduced calorie consumption without malnutrition, is the only natural regimen shown to extend maximum and mean lifespan, as well as healthspan in a wide range of organisms. Although the knowledge about the biological mechanisms underlying CR is still incipient, various appr...
متن کاملThe effects of calorie restriction on aging: a brief review.
Calorie restriction (CR) without malnutrition slows aging and increase average and maximal lifespan in model organisms and rodents. In human and non-human primates, CR has beneficial effects on human longevity and reduces the incidence of age-related diseases such as obesity, diabetes mellitus hypertension, cardiovascular disease and cancer. CR exerts its anti-aging effects through different me...
متن کاملPlasma glucose and the action of calorie restriction on aging.
We tested the hypothesis that retardation of aging by caloric restriction is due in part to decreased levels of plasma glucose over the life span. Male C57BL/6 mice expressing a human GLUT4 minigene (transgenic [TG] mice) and their nontransgenic littermates (NTG mice) were maintained under specific pathogen-free conditions. Mice were fed ad libitum (A mice) or 40% less than ad libitum (R mice) ...
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ژورنال
عنوان ژورنال: Exercise and Sport Sciences Reviews
سال: 2019
ISSN: 1538-3008,0091-6331
DOI: 10.1249/jes.0000000000000193